Final answer:
The middle stage of Alzheimer’s disease is primarily associated with increased difficulty in performing daily tasks due to significant cognitive decline and personality changes. This stage involves more dependency on others for care and an overall decline in the patient’s ability to manage routine activities.
Step-by-step explanation:
The challenge of the middle stage of Alzheimer’s disease best corresponds to B) Difficulty with daily tasks. During this stage, individuals with Alzheimer's experience significant disruptions to their cognitive abilities, making it challenging for them to perform routine tasks. This can include issues with grooming, dressing, cooking, and overall personal care.
Symptoms characteristic of Alzheimer's include disruptive memory loss, confusion about time or place, and marked changes in personality. These symptoms exacerbate the difficulty with daily activities. Moreover, the middle stage is distinguished by an increased dependency on others for assistance.
The disease progresses from mild cognitive impairment (MCI), a precursor stage, to moderate and severe AD where the changes in the brain, including the development of amyloid plaques and neurofibrillary tangles, lead to further cognitive decline and physical impairment.