Question

Match the features to either the sequential or concerted model of allosteric regulation

A. Sequential: Cooperative binding
B. Sequential: Non-cooperative binding
C. Concerted: Cooperative binding
D. Concerted: Non-cooperative binding

Answer 1

In allosteric regulation, the sequential model involves cooperative binding while the concerted model involves simultaneous conformational changes in all subunits of the enzyme.

Step-by-step explanation:

The features of sequential and concerted models of allosteric regulation can be matched as follows:

1. Sequential: Cooperative binding - A
2. Sequential: Non-cooperative binding - B
3. Concerted: Cooperative binding - C
4. Concerted: Non-cooperative binding - D

In sequential models of allosteric regulation, binding of the regulator molecule to one subunit of the enzyme affects the other subunits, leading to cooperative binding. This can result in a sigmoidal (S-shaped) enzyme activity curve.

In concerted models, all subunits of the enzyme undergo conformational changes simultaneously upon binding of the regulator molecule. This leads to a rapid transition between active and inactive states of the enzyme.