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How to convert 1-phenylethanol to methyl 1-phenylethyl sulfide?

A. Oxidize with potassium permanganate
B. React with methyl magnesium bromide
C. Treat with thionyl chloride and methyl mercaptan
D. Perform a Fischer esterification with sulfuric acid and methanol

1 Answer

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Final answer:

To convert 1-phenylethanol to methyl 1-phenylethyl sulfide, use thionyl chloride and methyl mercaptan to perform a nucleophilic substitution, replacing the alcohol group with a sulfide group.

Step-by-step explanation:

To convert 1-phenylethanol to methyl 1-phenylethyl sulfide, you would treat 1-phenylethanol with thionyl chloride and methyl mercaptan. This involves the nucleophilic substitution of the hydroxyl group with a sulfide group from methyl mercaptan. The other options provided are not suitable for this transformation as they involve different reactions:

  • Oxidation with potassium permanganate would potentially oxidize the alcohol to a ketone or carboxylic acid, not form a sulfide.
  • Reacting with methyl magnesium bromide would add a Grignard reagent to the molecule, which is not the desired transformation.
  • Performing a Fischer esterification with sulfuric acid and methanol would form an ester, not a sulfide.

Therefore, the correct answer is C: Treat with thionyl chloride and methyl mercaptan. This reaction will replace the hydroxy group of the alcohol with a sulfide group from the methyl mercaptan, resulting in the formation of methyl 1-phenylethyl sulfide.

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