Final answer:
The Mississippi River is the waterway that connects the interior of North America with the Gulf of Mexico, serving as a significant route for commerce.
Step-by-step explanation:
The Mississippi River is an important waterway that connects the interior of North America with the Gulf of Mexico. It plays a significant role in domestic and international commerce by providing a transportation route for goods.
Notable, the Mississippi River and its tributaries form one of the largest river systems in the world, stretching across several U.S. states and serving as a key shipping and trade route.