Final answer:
A direct approach is preferable when there is little doubt of a subject's guilt in an interview setting, as it allows for straightforward questioning to acquire confirmatory information.
Step-by-step explanation:
When there is little doubt of a subject's guilt, an interviewer is better off using a direct approach. This method involves straightforward questioning to elicit information. The setting of the question appears to be focused on interview techniques in the context of law enforcement or legal interrogations, where the subject refers to a person being questioned about a crime. The approach taken should consider the evidence at hand and aim to obtain clear, confirmatory information. An indirect approach might be less effective and could introduce ambiguity in situations where guilt is scarcely in question.