Final answer:
The unique amino acid sequence of proteins determines their three-dimensional shape and function. It is this sequence that is most crucial for the protein's physical characteristics.
Step-by-step explanation:
The variations in the physical characteristics between different proteins are primarily influenced by the unique amino acid sequence. The correct answer to fill in the blank is (b) sequence. Proteins consist of chains of amino acids linked by peptide bonds. This unique sequence determines the protein's specific 3D conformation, which in turn affects the protein's function. Scientists have discovered that even a small change in the sequence can have a significant impact on the protein's structure and its ability to perform its function.