Question

A mutation was introduced to the original DNA and now you have following DNA sequence (the mutation is colored in red.).

5'-GGATGCATGCCCCTCAAAGGGTAAATT-3'(coding strand)
3'-CCTACGTACGGGGAGTTTCCCATTTAA-5'(template strand)
What is going to happen to the protein coded by this gene? Write expected amino acid sequence (like Pro-Arg-Tyr-)

Answer 1

The mutation in the DNA sequence is an insertion mutation, and it will cause a shift in the reading frame, resulting in an entirely different amino acid sequence.

Step-by-step explanation:

The mutation in the DNA sequence is a single nucleotide change where a T is inserted between G and A. This type of mutation is called an insertion mutation. The original DNA sequence in the coding strand is 5' GGATGCATGCCCCTCAAAGGGTAAATT-3'. After the mutation, the new DNA sequence becomes 5'-GGATGTCATGCCCCTCAAAGGGTAAATT-3'. The resulting amino acid sequence of the protein coded by this gene would be the same as the original sequence up until the site of the mutation. After the mutation, all the codons would shift, resulting in an entirely different amino acid sequence.