Final answer:
Flattening the highly folded mitochondrial inner membrane would decrease surface area for chemical reactions, reducing the efficiency of ATP production.
Step-by-step explanation:
The question pertains to the structural change in the mitochondrial inner membrane and its impact on cellular respiration. Changing the shape of the mitochondrial inner membrane from a highly folded surface to a smooth, flat surface will most likely result in a decreased surface area for chemical reactions. The inner membrane's folds, called cristae, significantly increase the surface area, which is crucial for the electron transport chain and ATP synthesis to occur efficiently. Therefore, flattening these folds would reduce the efficiency of ATP production, as there would be less surface area for the critical reactions of the electron transport chain and ATP synthase activity to take place.