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The cellular orchestration of metabolism is directed by _______ and mediated in major part by ___________ .

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Final answer:

The cellular orchestration of metabolism is directed by enzymatic control, particularly through allosteric enzymes that respond to cellular metabolite levels and is largely mediated by ATP, ADP, AMP, NAD+, and GLUT proteins.

Step-by-step explanation:

The cellular orchestration of metabolism is directed by enzymatic control and mediated in major part by nucleotides such as ATP, ADP, AMP, NAD+, and FAD.

Controlling the entry of glucose into a cell involves GLUT proteins, which facilitate the transport of glucose through the cell membrane.

Metabolic reactions are regulated to prevent reaching a state of equilibrium, thereby allowing the cell to produce balanced amounts of energy and shunt intermediates to pathways for synthesizing other macromolecules such as amino acids, proteins, and lipids.

Additionally, allosteric enzymes play a significant role by responding to the levels of metabolites that act as allosteric effectors. These enzymes enhance or reduce their catalytic activities based on the binding to their allosteric sites, which is crucial for maintaining appropriate metabolic flux according to the cellular energy demands and availability of resources.

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