Question

Considering the model in which proton diffusion is coupled in the F0 complex, how many protons would need to be translocated in order to obtain a full 360° rotation of the c ring and γ subunit to yield 3 ATP molecules?

Answer 1

A full 360° rotation of the c ring and γ subunit in the F0F1 ATP synthase complex, which yields 3 ATP molecules, requires the translocation of 12 protons.

Step-by-step explanation:

In the context of the ATP synthase mechanism, specifically the F0F1 ATPase complex within mitochondria, the proton-driven rotation of the c ring and γ (gamma) subunit facilitates the synthesis of ATP. The F0 portion consists of a ring of c subunits, and protons flowing through the channels between them provide the energy for rotation. According to the model in which each proton causes a rotation of 30° in the c ring, a full 360° rotation would require the translocation of 12 protons through the ATP synthase. Each 360° rotation of the F1 γ subunit results in the synthesis of three ATP molecules from ADP and phosphate.