Final answer:
Helicase is the protein out of the six that binds to oriC and has helicase activity. It separates the DNA strands at the origin of replication and precedes the replisome at the replication fork during DNA replication.
Step-by-step explanation:
Of the six proteins that bind to oriC, the one that has helicase activity and precedes the replisome at the replication fork during the course of DNA replication is helicase itself. Helicase is responsible for separating the DNA strands at the origin of replication by breaking the hydrogen bonds between the nitrogenous base pairs. As the DNA strands open up, replication forks are formed and the helicase moves ahead of the replisome to unwind the DNA and facilitate replication.