Question

If there is a ____ ____ ____ ___ mutation, E2F remains active, the normal control of the cell cycle is lost, and tumors form.

Answer 1

If there is a loss of function mutation in the p53 gene, E2F remains active, the normal control of the cell cycle is lost, and tumors form.

Step-by-step explanation:

If there is a loss of function mutation in the p53 gene, E2F remains active, the normal control of the cell cycle is lost, and tumors form. The loss of p53 function compromises the G₁ checkpoint and allows the cell to proceed directly from G₁ to S regardless of internal and external conditions. This results in the production of daughter cells that inherit the mutated p53 gene and have a higher risk of acquiring other mutations, leading to tumor growth.