Question

The substitution of Abl's normal N-terminus for the N-terminal

fragment of the Bcr protein makes it ________

Answer 1

The substitution turns Abl's normal N-terminus into a constitutively active form creating the Bcr-Abl fusion protein which leads to uncontrolled cell division, commonly seen in chronic myelogenous leukemia.

Step-by-step explanation:

The substitution of Abl's normal N-terminus for the N-terminal fragment of the Bcr protein makes it constitutively active. In biological terms, this refers to the creation of the Bcr-Abl fusion protein, which is commonly associated with chronic myelogenous leukemia (CML). The Bcr-Abl oncogene is generated through a specific chromosomal translocation known as the Philadelphia chromosome. This leads to the tyrosine kinase activity of Abl that is no longer regulated, causing uncontrolled cell division and the development of leukemia.