Question

Bcl2 proteins are grouped into 3 classes, depending on which ______ domains they contain.

Answer 1

Bcl2 proteins are categorized into three classes based on the BH domains they possess, which are significant in apoptosis regulation.

Step-by-step explanation:

Bcl2 proteins are grouped into 3 classes, depending on which BH domains they contain. These proteins play a critical role in the regulation of apoptosis, and their classification is based on the presence of up to four Bcl-2 Homology (BH) domains, which are BH1, BH2, BH3, and BH4. The three main classes of Bcl2 proteins include anti-apoptotic proteins (e.g., Bcl-2, Bcl-XL), pro-apoptotic proteins (e.g., Bax, Bak), and BH3-only proteins (e.g., Bid, Bim). Each class interacts differently with the apoptosis pathways within the cell, contributing to the delicate balance between cell survival and programmed cell death.