Question

In the intrinsic pathway, Cytochrome c binds an adapter protein, which recruits

procaspases, resulting in the formation of the ________,
a complex that activates initiator caspases.

Answer 1

Cytochrome c released from mitochondria binds to an adaptor protein forming the apoptosome, which activates initiator caspases involved in apoptosis.

Step-by-step explanation:

In the intrinsic pathway of apoptosis, Cytochrome c plays a pivotal role when released from mitochondria into the cytoplasm. Here, Cytochrome c binds to an adaptor protein which then recruits inactive procaspases. This interaction results in the formation of a multi-protein complex known as the apoptosome, a complex that activates initiator caspases. These initiator caspases then go on to activate executioner caspases, leading to the cell's dismantlement and death. The apoptosome functions as a critical platform for the activation of the caspases, thereby propelling the apoptosis machinery forward.