Final answer:
Prokaryotic chromosomes are packed by large regions of positively supercoiled DNA and do not involve histones or histone-like proteins. Furthermore, prokaryotes lack higher-level structures such as looped domains that are present in eukaryotes.
Step-by-step explanation:
The packaging of prokaryotic chromosomes involves large regions of positively supercoiled DNA but lacks histones or histone-like proteins. Unlike eukaryotes, prokaryotes do not have histone proteins to wrap their DNA around. Instead, they use DNA gyrase, an enzyme that helps supercoil the DNA. Prokaryotic chromosomes also lack higher-level structures such as looped domains that are present in eukaryotes.