Question

Which of the following statements regarding positive selection is correct?

a. All subsets of developing T cells undergo positive selection before export to the peripheral circulation.
b. T-cell receptor editing is linked to the process of positive selection.
c. Positive selection results in the production of T cells bearing T-cell receptors that have the capacity to interact with all allotypes of MHC class I and class II molecules, and not just those of the individual.
d. Positive selection ensures that autoreactive T cells are rendered non-responsive.
e. If there is a genetic defect in AIRE, then T-cell development is arrested as positive selection commences.

Answer 1

Positive selection in thymic selection ensures the production of T cells with T-cell receptors that can interact with MHC class I and class II molecules.

Step-by-step explanation:

Positive selection is a step in thymic selection that occurs in the cortex of the thymus. It involves the selection of T cells that can interact appropriately with major histocompatibility complex (MHC) molecules. Thymocytes that interact appropriately with MHC molecules receive a positive stimulation, whereas those that do not are not stimulated and are eliminated by apoptosis. This process ensures the production of T cells with T-cell receptors that have the capacity to interact with MHC class I and class II molecules.