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There are many parallels between the development of B cells and T cells. Identify the incorrectly matched counterpart in B cells (left) versus T cells (right).

a. VpreBλ5: pTα
b. Igα/Igβ:CD3
c. Pax-5: FoxP3
d. multiple κ and λ light-chain gene rearrangements: multiple α-chain gene rearrangements.

User Gjergji
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1 Answer

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Final answer:

The incorrectly matched counterpart in the development of B cells compared to T cells is Pax-5: FoxP3, as Pax-5 is crucial for B cell development, and FoxP3 is associated with regulatory T cells, not naive T cell development.

Step-by-step explanation:

The correctly matched counterparts in development of B cells and T cells are VpreBλ5 to pTα and Igα/Igβ to CD3, since these pairs represent analogous components between B cells and T cells in their development. However, the incorrectly matched counterpart from the options provided is Pax-5: FoxP3. Pax-5 is a transcription factor involved in B cell development, whereas FoxP3 is a transcription factor most closely associated with the regulation of regulatory T cells (Tregs), not a direct counterpart in the development of naive T cells. In B cells, light-chain gene rearrangements produce multiple κ and λ light chains, while in T cells, multiple α-chain gene rearrangements contribute to TCR diversity, correctly reflecting the counterparts in antigen receptor gene rearrangement processes.

User Magno
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