127k views
5 votes
There are many parallels between the development of B cells and T cells. Identify the incorrectly matched counterpart in B cells (left) versus T cells (right).

a. VpreBλ5: pTα
b. Igα/Igβ:CD3
c. Pax-5: FoxP3
d. multiple κ and λ light-chain gene rearrangements: multiple α-chain gene rearrangements.

User Gjergji
by
8.1k points

1 Answer

7 votes

Final answer:

The incorrectly matched counterpart in the development of B cells compared to T cells is Pax-5: FoxP3, as Pax-5 is crucial for B cell development, and FoxP3 is associated with regulatory T cells, not naive T cell development.

Step-by-step explanation:

The correctly matched counterparts in development of B cells and T cells are VpreBλ5 to pTα and Igα/Igβ to CD3, since these pairs represent analogous components between B cells and T cells in their development. However, the incorrectly matched counterpart from the options provided is Pax-5: FoxP3. Pax-5 is a transcription factor involved in B cell development, whereas FoxP3 is a transcription factor most closely associated with the regulation of regulatory T cells (Tregs), not a direct counterpart in the development of naive T cells. In B cells, light-chain gene rearrangements produce multiple κ and λ light chains, while in T cells, multiple α-chain gene rearrangements contribute to TCR diversity, correctly reflecting the counterparts in antigen receptor gene rearrangement processes.

User Magno
by
7.0k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.