Question

Which of the following immunodeficiency matches are incorrect? Mark all that apply.

a. IL-7 receptor deficiency: absence of T cells because of signaling defects by thymic stromal cells
b. DiGeorge syndrome: absence of T cells due to absence of thymus
c. IPEX: absence of functional AIRE
d APECED: absence of functional FoxP3
e. Bare lymphocyte syndrome: absence of functional MHC class I or MHC class II molecules

Answer 1

Option A) and E). The incorrect matches among the given immunodeficiencies are IL-7 receptor deficiency and Bare lymphocyte syndrome.

Step-by-step explanation:

The incorrect matches among the given immunodeficiencies are:

• a. IL-7 receptor deficiency: This immunodeficiency is characterized by absence of T cells due to lack of signaling from IL-7 receptor on thymic stromal cells, leading to impaired development of T cells
• b. DiGeorge syndrome: This syndrome is caused by absence or underdevelopment of the thymus, resulting in absence or deficiency of T cells
• c. IPEX: This immunodeficiency is characterized by absence of functional AIRE gene, leading to autoimmune conditions
• d. APECED: This immunodeficiency is characterized by absence of functional FoxP3 gene, leading to autoimmune polyendocrinopathy
• e. Bare lymphocyte syndrome: This immunodeficiency is characterized by absence of functional MHC class II molecules, resulting in impaired antigen presentation to T cells

Therefore, the incorrect matches are a. IL-7 receptor deficiency and e. Bare lymphocyte syndrome.