Question

In lymph nodes of mice that lack AIRE the following abnormalities may occur:

a. Mice will not have any T cells in lymph nodes.
b. There will be an excessive number T cells in lymph nodes that will die from apoptosis
c. In mice that lack AIRE thymocytes can not mature therefore they accumulate in the thymus in an immature stage.
d. In mice that lack AIRE, thymocytes will mature but remain autoreactive against tissue antigens and accumulate in the lymph node and peripheral tissues.
e. In mice that lack AIRE, thymocytes will mature but remain anergic against tissue antigens.

Answer 1

Option C). The absence of AIRE in mice can lead to various abnormalities in lymph nodes, such as a lack of T cells or an excessive number of T cells that undergo apoptosis. In mice lacking AIRE, thymocytes may not mature properly or exhibit autoreactivity or anergy against tissue antigens.

Step-by-step explanation:

Abnormalities in Mice Lacking AIRE in Lymph Nodes:

In mice that lack AIRE, the following abnormalities may occur:

1. Mice will not have any T cells in lymph nodes.
2. There will be an excessive number T cells in lymph nodes that will die from apoptosis.
3. In mice that lack AIRE, thymocytes cannot mature, therefore they accumulate in the thymus in an immature stage.
4. In mice that lack AIRE, thymocytes will mature but remain autoreactive against tissue antigens and accumulate in the lymph node and peripheral tissues.
5. In mice that lack AIRE, thymocytes will mature but remain anergic against tissue antigens.

This suggests that AIRE plays a crucial role in the development and regulation of T cells in lymph nodes and thymus.