Final answer:
In managing gestational hypertension, ACE inhibitors, candesartan, and other angiotensin II receptor blockers like eprosartan and irbesartan should be avoided due to their potential to cause fetal harm, including renal failure, oligohydramnios, and skeletal deformities.
Step-by-step explanation:
In pregnancy, certain medications used for the treatment of hypertension should be avoided due to their potential to cause harm to the fetus. Here is a list of four drugs that should not be used to treat gestational hypertension:
- Angiotensin-converting enzyme (ACE) inhibitors - These drugs can cause fetal renal failure and oligohydramnios, leading to pulmonary hypoplasia and limb contractures. They can also result in fetal cranial bone abnormalities.
- Candesartan (Atacand) - This medication is classified as an angiotensin II receptor blocker and carries similar risks as ACE inhibitors for the fetus.
- Angiotensin II receptor blockers - Like candesartan, other drugs in this class, such as Eprosartan (Teveten) or Irbesartan (Avapro), are contraindicated as they can lead to adverse fetal outcomes.
These medications should be avoided in pregnant women due to their association with fetal complications. Alternative antihypertensive agents should be considered that are safer for use during pregnancy.