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The clamp

β dimer makes holoenzyme highly ____
β dimer bound to DNA but slides along
β dimer is ring shaped; assembly or removal requires ___ (γδ)

User Redplane
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Final answer:

The β dimer, part of the DNA polymerase holoenzyme, increases DNA synthesis processivity and requires γδ subunits for its assembly and removal around DNA.

Step-by-step explanation:

The student's question is related to the structure and function of the DNA replication machinery, specifically the role of the sliding clamp, known as the β dimer, and how it relates to the DNA polymerase holoenzyme. The β dimer is ring-shaped which encircles DNA and allows the DNA polymerase to maintain a strong association with the template, making the holoenzyme highly processive. This means that once the DNA polymerase is bound to DNA, it can synthesize a long stretch of DNA without dissociating. As for the assembly or removal of the β dimer, it requires the action of clamp loader proteins, specifically the subunits γδ. These subunits are responsible for opening and closing the β dimer ring so it can load onto the DNA and be removed when necessary. This process is crucial for the function of DNA polymerases during DNA replication.

User Gareth Rees
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