Question

Of the six proteins that bind to oriC, which one is unique to the origin, can not rebind, and is, therefore, analogous to the eukaryotic Licensing Factor?

Answer 1

DnaA is the protein that is unique to the oriC in prokaryotes, cannot rebind after functioning, and is analogous to the eukaryotic Licensing Factor, regulating the initiation of DNA replication.

Step-by-step explanation:

The protein that is unique to the origin of replication (oriC) in prokaryotes and does not rebind once it has functioned, analogous to the eukaryotic Licensing Factor, is DnaA. The origin of replication is a specific nucleotide sequence where proteins bind to initiate DNA replication. In E. coli, DnaA is responsible for the initial step in unwinding the DNA helix, allowing helicase and other replication proteins to bind and commence replication. Once DnaA has bound and fulfilled its role, it cannot bind again, ensuring that replication occurs only once per cell cycle, thus serving a similar function to the eukaryotic Licensing Factor that regulates replication in eukaryotic cells.