Question

Events that occur at the origin of DNA replication of the chromosomal ____.

Tension is relaxed in the supercoiled genome by ____.

Initiation involves the recognition of the origin by ____ protein.

At the end of replication, ____ and ____ must occur.

Answer 1

DNA replication begins with the unwinding of DNA at the origin of replication. Topoisomerase relaxes the supercoiled chromosome, initiator proteins recognize the origin, and at the end of replication, RNA primers are replaced with DNA and fragments are joined by DNA ligase.

Step-by-step explanation:

The events that occur at the origin of DNA replication on a chromosomal level involve several steps and key proteins. First, tension is relaxed in the supercoiled genome by topoisomerase. The initiation of replication involves the recognition of the origin by initiator proteins. At the end of DNA replication, removal of the RNA primer and joining of the newly synthesized DNA fragments, known as ligation, must occur.

• DNA unwinds at the origin of replication.
• Topoisomerase relaxes the supercoiled chromosome to reduce tension.
• Initiator proteins recognize the origin of replication to start the process.
• At the end of replication, RNA primers are replaced with DNA, and DNA ligase performs the ligation to join DNA fragments.