Final answer:
It is true that during DNA replication, the two DNA strands' anti-parallel nature means one template is 5' to 3' and the other is 3' to 5', leading to continuous leading strand synthesis toward the fork and discontinuous lagging strand synthesis in Okazaki fragments away from the fork.
Step-by-step explanation:
The statement that as DNA unwinds during replication, one template is exposed in the 5' to 3' direction, and the other template is exposed in the 3' to 5' direction is true.
During DNA replication, DNA polymerase can only synthesize new DNA in the 5' to 3' direction. Due to the anti-parallel nature of the DNA strands, the leading strand is synthesized continuously in the direction of the replication fork, complementary to the 3' to 5' parental DNA strand.
In contrast, the lagging strand is synthesized in Okazaki fragments away from the replication fork, complementary to the 5' to 3' parental DNA strand. Each Okazaki fragment starts with a primer and is extended in the 5' to 3' direction, ultimately being joined together to form the complete strand.