Final answer:
The Central Dogma of Molecular Biology is the principle that genetic information flows from DNA to RNA to protein and cannot be transferred back from protein to nucleic acid.
Step-by-step explanation:
The Doctrine of the Triad and the Central Dogma
The question pertains to what is known as the Central Dogma of Molecular Biology, which was first articulated by Francis Crick in 1958. The Central Dogma states that biological information is transferred from DNA to RNA and then to protein, but not in reverse. In essence, this means that the information contained within the amino acid sequence of a protein cannot be transferred back into nucleic acid sequence, which encodes for the protein. This principle is fundamental to understanding genetic information flow within a biological system.
The phrase 'Once information has got into a protein it can't get out again' is the succinct summary of this principle. This underscores the unidirectionality of genetic information flow, beginning from DNA transcription to produce RNA, which is then translated to form the sequence of amino acids in a protein. The 'information' refers to the order of amino acids, which determines a protein's structure and function.