Question

What is the term for a situation where a mutation in a gene results in a protein that disrupts a protein-protein interaction, and a second mutation in a different gene results in a protein that restores this interaction?

A) Suppressor mutation
B) Nonsense mutation
C) Silent mutation
D) Frameshift mutation

Answer 1

A second mutation that restores the protein-protein interaction disrupted by a first mutation is called a Suppressor mutation.

Step-by-step explanation:

The term for a situation where a mutation in one gene results in a protein that disrupts a protein-protein interaction, and a second mutation in a different gene results in a protein that restores this interaction, is a Suppressor mutation. This type of mutation can effectively 'cancel out' the effect of the original mutation, which might have led to a non-functional protein or an altered protein-protein interaction. Such suppressor mutations do not directly reverse the original mutation but compensate for its effects through a different pathway or by changing another component of the cell's machinery.