Question

What are the following caused by and some symptoms? Angelman syndrome Prader-Willi syndrome

A) Angelman syndrome: Deletion of maternal chromosome 15; Symptoms: Developmental delay, ataxia
B) Angelman syndrome: Deletion of paternal chromosome 15; Symptoms: Hyperphagia, obesity
C) Prader-Willi syndrome: Deletion of maternal chromosome 15; Symptoms: Hypotonia, feeding difficulties
D) Prader-Willi syndrome: Deletion of paternal chromosome 15; Symptoms: Seizures, microcephaly

Answer 1

Angelman syndrome is caused by the deletion of maternal chromosome 15 and includes symptoms like developmental delay and ataxia. Prader-Willi syndrome is due to the deletion of paternal chromosome 15 and features symptoms like hypotonia and later hyperphagia leading to obesity.(option a)

Step-by-step explanation:

Angelman syndrome and Prader-Willi syndrome are genetic disorders caused by abnormalities in chromosome 15. Angelman syndrome is typically caused by the deletion of a segment of the maternal chromosome 15. Symptoms of Angelman syndrome include developmental delays, lack of speech, balance disorders (ataxia), and typically a happy demeanor.

On the other hand, Prader-Willi syndrome is caused by the lack of genetic material in the paternal chromosome 15. This syndrome is characterized by symptoms such as low muscle tone (hypotonia), feeding difficulties in infancy, followed by hyperphagia leading to obesity, and cognitive impairments.