Question

Malabsorption from persistent cholestasis can lead to which vitamin deficiency?What pregnancy complication can this cause?

A) Vitamin A deficiency; night blindness
B) Vitamin D deficiency; rickets
C) Vitamin K deficiency; bleeding disorders
D) Vitamin E deficiency; neurological abnormalities

Answer 1

Persistent cholestasis can lead to malabsorption of fat-soluble vitamins, including vitamin D and K. Vitamin D deficiency can cause rickets, and vitamin K deficiency can lead to bleeding disorders during pregnancy.

Step-by-step explanation:

Malabsorption and Vitamin Deficiencies:

Malabsorption from persistent cholestasis can lead to deficiencies in fat-soluble vitamins, such as vitamin A, D, E, and K. Among these, vitamin D deficiency is associated with rickets in children a condition characterized by bowed legs due to improper bone development. This occurs because vitamin D is vital for calcium absorption and bone health. In the context of pregnancy, vitamin K deficiency due to malabsorption can lead to bleeding disorders, as vitamin K is crucial for the synthesis of clotting factors.

Vitamin A deficiency can cause night blindness, while vitamin E deficiency is associated with neurological abnormalities. However, in the setting of pregnancy complications specifically related to malabsorption from cholestasis, vitamin K deficiency and subsequent bleeding disorders are the prominent concerns. Ensuring adequate vitamin levels is critical during pregnancy to prevent such complications.