Final answer:
The major factor that contributes to an age-related decline in endurance performance is a decline in exercise economy. Aging leads to a loss of muscle mass and strength, resulting in a reduced ability to produce powerful contractions. This decline in muscle mass causes a loss of endurance and stamina, particularly in activities that require strength and powerful movements.
Step-by-step explanation:
The major factor that contributes to an age-related decline in endurance performance is a decline in exercise economy. Aging leads to a loss of muscle mass and strength, resulting in a reduced ability to produce powerful contractions. This decline in muscle mass causes a loss of endurance and stamina, particularly in activities that require strength and powerful movements.