Final answer:
True, the protein synthesis process starts at the N-terminus and the C-terminus is synthesized last, which is consistent with the directionality of how proteins are synthesized.
Step-by-step explanation:
The statement 'The C-terminus of the protein is synthesized last' is true. Protein synthesis, or translation, begins at the N-terminus and ends at the C-terminus. This process of elongation continues until the entire polypeptide is synthesized, with the addition of amino acids occurring at the carboxyl end as the polypeptide chain grows. Studies show that proteins are synthesized from the N-terminal to the C-terminal, a fundamental principle in molecular biology. During this process, secretory proteins may have a signal sequence at the N-terminus that is removed once the protein reaches its destination, indicating the polypeptide's directionality of synthesis.