Question

Drug that contraindicates with the use of PDE-5 inhibitor (sildenafil) is:

a) Nitroglycerin
b) Aspirin
c) Amiodarone
d) Amlodipine

Answer 1

The drug that has a contraindication with the use of the PDE-5 inhibitor sildenafil is option a)Nitroglycerin, due to the risk of an unsafe drop in blood pressure from combined vasodilation effects.

Step-by-step explanation:

The drug that contraindicates with the use of PDE-5 inhibitor (sildenafil) is a) Nitroglycerin. Sildenafil works by inhibiting the enzyme PDE5, which increases blood flow and allows vasodilation. Nitroglycerin, a medication used for treating angina, also works by vasodilation through the release of nitric oxide (NO). Using these two drugs together can lead to an unsafe drop in blood pressure. Therefore, patients taking nitrates like nitroglycerin should avoid using PDE5 inhibitors like sildenafil.