Final answer:
The first-line pharmacotherapy for enuresis is Desmopressin, a medication that helps reduce nighttime urine production.
Step-by-step explanation:
The first-line pharmacotherapy for enuresis (>5 years old with >2 accidents per week) is Desmopressin. Desmopressin is a synthetic analog of the hormone vasopressin, which helps to decrease nighttime urine production. This medication works by reducing the amount of urine that the body produces during sleep, leading to improved control of bladder function.
Oxybutynin, Tolterodine, and Imipramine are not typically used as first-line treatments for enuresis. Oxybutynin and Tolterodine are anticholinergic medications that are commonly used to treat overactive bladder, while Imipramine is an antidepressant that may be prescribed in certain cases of enuresis. However, these medications are generally considered second-line options or used in specific circumstances.