Question

Infant with lethargy, hoarse cry, poor feeding, constipation, jaundice, dry skin, and large fontanelles. Labs show increased TSH and decreased T4:

a) Down syndrome
b) Hypoparathyroidism
c) Congenital adrenal hyperplasia
d) Congenital hypothyroidism

Answer 1

Congenital hypothyroidism is the most likely condition based on the symptoms described in the question. It can lead to cretinism and is treated with thyroid hormone replacement therapy.

Step-by-step explanation:

The symptoms described in the question, such as lethargy, hoarse cry, poor feeding, constipation, jaundice, dry skin, and large fontanelles, are indicative of congenital hypothyroidism. This condition occurs when there is insufficient production of thyroid hormones in infants. Hypothyroidism in infants can lead to cretinism, which is characterized by dwarfism, thick tongue and skin, mental health, and sexual underdevelopment. Treatment for congenital hypothyroidism usually involves thyroid hormone replacement therapy.