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Cancer-associated fibroblasts (CAFs) in TME

A) Plasma cells
B) Mast cells
C) Fibrocytes
D) Memory B cells

User Omegaspard
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1 Answer

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Final answer:

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are identified as fibrocytes, which are fixed cells within the connective tissue. Other options such as plasma cells, mast cells, and memory B cells, play different roles associated with the immune system.

Step-by-step explanation:

The student's question is concerning the identity of cancer-associated fibroblasts (CAFs) within the Tumor Microenvironment (TME). Based on reference information provided, fibrocytes are the correct answer as they are a type of fixed cell that remains within connective tissue. This is relevant since fibroblasts, which are precursors to fibrocytes, are crucial in connective tissue proper.

The other options listed, such as plasma cells, mast cells, and memory B cells, are part of the immune system and are not commonly referred to as cancer-associated fibroblasts. Moreover, it is known that plasma cells produce antibodies and play a role in type II hypersensitivity reactions along with other immune responses, and mast cells are involved in allergic reactions and the release of histamines. Memory B cells are involved in retaining information about pathogens to produce a swift response upon re-exposure; however, they are not fibroblasts.

User Bianka
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