Question

Drug targets of: - fluoroquinolones - tetracycline - amino glycosides - macrolides=> bactericidal or static?

A) Bactericidal
B) Bacteriostatic
C) Virucidal
D) Virustatic

Answer 1

Fluoroquinolones and aminoglycosides are generally bactericidal, targeting DNA gyrase and ribosomal 30S subunit, respectively. Tetracyclines and macrolides are typically bacteriostatic, inhibiting protein synthesis by blocking tRNA association with the ribosome or binding to the 50S subunit.

Step-by-step explanation:

The drug targets of various antimicrobial agents and whether they are bactericidal or bacteriostatic can be summarized as follows:

• Fluoroquinolones: These drugs, such as ciprofloxacin and levofloxacin, target bacterial DNA gyrase resulting in inhibition of DNA replication. They are generally bactericidal.
• Tetracyclines: This class of antibiotics, which includes doxycycline, inhibits protein synthesis by blocking the association of tRNA with the ribosome and is typically bacteriostatic.
• Aminoglycosides: Including gentamicin and streptomycin, these bind to the 30S subunit of the ribosome and interfere with protein synthesis. Aminoglycosides are usually bactericidal.
• Macrolides: Drugs like erythromycin and azithromycin inhibit protein synthesis by binding to the 50S subunit of the ribosome. They are often bacteriostatic but can be bactericidal in higher concentrations or against susceptible bacterial populations.

Answering the original question, fluoroquinolones and aminoglycosides are generally considered bactericidal, whereas tetracyclines and macrolides can be bacteriostatic. Therefore, the answer represented by the choices given would be dependent on the specific drug in question.