Final answer:
Corticosteroids are the primary drugs used to reduce skin inflammation by suppressing the immune response and reducing histamine production, while antihistamines prevent histamine effects and are used for milder allergic reactions.
Step-by-step explanation:
The drugs used for reducing skin inflammation are B) Corticosteroids. These medications, such as hydrocortisone creams, are applied to the skin to reduce inflammation by suppressing the immune system's response and minimizing the production of histamine, which can cause itching and swelling. Antihistamines can also be used to prevent histamines from causing these reactions and are commonly used in treating milder allergic reactions and some types of hypersensitivity reactions. Antibiotics would be used to treat bacterial infections, while antifungal medications target fungal infections, neither of which are primarily for reducing inflammation unless it is due to an infectious etiology.