Final answer:
Activation of μ-opioid receptors inhibits itching.
Step-by-step explanation:
The relationship between pruritus and activation of μ-opioid receptors is that it inhibits itching.
When μ-opioid receptors are activated, endogenous opioids are released which suppress the itch sensation in the skin. These opioids act on the μ-opioid receptors in the spinal cord and brain to reduce itch perception. Therefore, activating μ-opioid receptors can provide relief from pruritus.