Final answer:
The chemical mediators responsible for cutaneous itch include histamine, serotonin, and prostaglandins; thus, all are correct. These are released by mast cells and can be mitigated by antihistamines.
Step-by-step explanation:
The chemical mediators of cutaneous itch are A) Histamine, B) Serotonin, and C) Prostaglandins, meaning the correct answer is D) All of the above. These substances are released by mast cells when the body reacts to an irritant or allergen. Antihistamines can be used to prevent the effects of histamines, such as itching and swelling. Chemical mediators like histamine play a crucial role in various types of hypersensitivity reactions, including both type I and type II hypersensitivities.