Final answer:
Nerve compression is an anatomical lesion that can cause itching, often related to neuropathic pruritus where nerve damage leads to heightened itch signals.
Step-by-step explanation:
An anatomical lesion that can cause itching is nerve compression. This condition is related to neuropathic pruritus, where itchiness results from damage to neurons of the peripheral or central nervous system. Neuropathic pain occurs when these damaged nerves send exaggerated signals to the brain, and similarly, signals related to itch can be heightened. An example of a topographic mapping related to the location of sensory endings in the skin is seen in dermatomes, which are associated with spinal nerves containing sensory fibers. Itchiness can stem from various issues such as skin rashes from eczematous reactions, fungal infections, or even scar tissue, but when related to the nerves, such as in nerve compression, it is classified as neuropathic pruritus.