Question

All the TLRs use the MyD88, except ____, which uses ____ and activates what?

A) TLR3, TRIF, interferon production
B) TLR4, TRAM, NF-kappaB pathway
C) TLR5, MAL, MAP kinase cascade
D) TLR7, IRAK4, inflammasome

Answer 1

The sole exception among Toll-Like Receptors (TLRs) in not using MyD88 is TLR3, which employs TRIF to initiate interferon production.

Step-by-step explanation:

All Toll-Like Receptors (TLRs) utilize the adaptor protein MyD88 for signal transduction, with the exception of TLR3, which instead uses the adaptor protein TRIF. The activation of TLR3 leads to the production of type I interferons and other inflammatory cytokines that are part of an immediate innate immune response. Therefore, the correct answer to the given question is A) TLR3, TRIF, interferon production.