Question

What chemokine attracts the naive T lymphocyte into the surrounding tissue and what receptor does it bind?

A) CXCL12 - CXCR4
B) CCL2 - CCR2
C) CXCL10 - CXCR3
D) CCL5 - CCR5

Answer 1

The chemokine CXCL12 attracts naive T lymphocytes into the surrounding tissue by binding to the receptor CXCR4, option A is correct.

Step-by-step explanation:

The chemokine that attracts the naive T lymphocyte into the surrounding tissue is CXCL12, and it binds to the receptor CXCR4, making the correct answer A) CXCL12 - CXCR4. Naive T cells, which can be either CD4+ or CD8+, are attracted to the site of potential infection by chemokines where they can encounter antigen-presenting cells (APCs). Once engaged with APCs, CD4+ T cells bind to antigens presented with MHC II molecules while CD8+ T cells bind to antigens presented with MHC I molecules. This engagement is a critical initial step in the T cell's activation and subsequent immune response.