Final answer:
Strong ligation of IgM by self antigen leads to either anergy or deletion of B cells, with clonal deletion involving apoptosis and clonal anergy rendering B cells nonfunctional to prevent autoimmunity.
Step-by-step explanation:
The question relates to the immune system's mechanisms for preventing autoimmunity, specifically within B cell tolerance. Strong ligation of IgM by self antigen induces either anergy or deletion. Central tolerance mechanisms such as clonal deletion remove potentially self-reactive B cells by inducing apoptosis, while clonal anergy makes B cells nonfunctional, though physically intact, preventing them from participating in immune responses to self-antigens. Neither hypermutation, switching, proliferation, differentiation, tolerance, nor activation are immediate consequences of strong self-antigen ligation on IgM. Therefore, the correct answer to the question is A) Anergy, deletion.