Question

Blockade of this receptor system is most likely associated with akathisia, a side effect of antipsychotic treatment:

a. Dopamine D1 receptors

b. Dopamine D2 receptors

c. Serotonin 5-HT1A receptors

d. Norepinephrine alpha-2 receptors

Answer 1

Akathisia as a side effect of antipsychotic treatment is most commonly linked to the blockade of Dopamine D2 receptors.

Step-by-step explanation:

The side effect of akathisia, which is associated with antipsychotic treatment, is most likely linked to the blockade of Dopamine D2 receptors. Antipsychotics function as antagonists to dopamine, hindering its effects by occupying these receptors without activating them, subsequently preventing dopamine from sending signals to adjacent neurons. This leads to a reduction in dopamine activity, particularly in the basal ganglia, a brain region associated with movement regulation.