Final answer:
Orthornithine Transcarbamylase Deficiency leads to Hyper-ammonemia type-II, resulting in the toxic buildup of ammonia in the blood due to the defective urea cycle.
Step-by-step explanation:
Orthornithine Transcarbamylase Deficiency is a genetic disorder characterized by a deficiency in the enzyme ornithine transcarbamylase, which leads to a condition known as Hyper-ammonemia type-II. This enzyme plays a critical role in the urea cycle, which helps to eliminate excess nitrogen from the body. Due to this deficiency, toxic levels of ammonia build up in the blood (hyperammonemia), which can lead to various neurological impairments and other clinical symptoms. The condition is inherited in an X-linked manner, which means it primarily affects males.