Question

Considering the pathway location of Anderson, Von Girke, Cori Disease, McArdle's, and Herr's Disease, which option correctly arranges them in sequence?

Answer 1

The sequence in the glycogen metabolism pathway is Anderson, Von Gierke, Cori, McArdle's, and Hers' disease, reflecting the order from glycogen formation to breakdown.

Step-by-step explanation:

The question deals with the sequence of disorders along the glycogen metabolism pathway. In glycogen metabolism, Anderson disease (glycogen branching enzyme deficiency) occurs at the point of glycogen branching, while Von Gierke disease (glycogen storage disease type I) is related to glucose-6-phosphatase deficiency affecting glucose production from glycogen. Cori disease (glycogen storage disease type III) involves the debranching enzyme deficiency. McArdle's disease (glycogen storage disease type V) affects muscle phosphorylase, impacting the breakdown of glycogen in muscle tissue. Finally, Hers' disease (glycogen storage disease type VI) is due to liver phosphorylase deficiency affecting glycogenolysis in the liver.

Hence, the correct sequence reflecting their positions in the metabolic pathway from glycogen formation to breakdown is Anderson, Von Gierke, Cori, McArdle's, and Hers' disease.