Final answer:
The steps of forming aggregates in Huntington's disease involve the misfolding and aggregation of mutant huntingtin protein in the brain.
Step-by-step explanation:
The steps of forming aggregates in Huntington's disease (HD) involve the abnormal clumping of mutant huntingtin protein (mHTT) in the brain. Here are the steps:
- Misfolding of mHTT: Mutated huntingtin protein misfolds, meaning it adopts an abnormal shape.
- Aggregation: Misfolded mHTT starts to aggregate and forms clumps or inclusion bodies.
- Formation of aggregates: These inclusion bodies grow larger over time and disrupt normal cellular functions in the brain.
These aggregates are a hallmark of HD and are thought to contribute to the progression of the disease.