Final answer:
Proper protein function is contingent on precise folding into a three-dimensional structure, aided by chaperones in some cases, and can be hindered by abnormal temperature or pH.
Step-by-step explanation:
Proper protein function requires the molecule to fold into a precise three-dimensional structure. Many proteins fold spontaneously, however, some require the aid of special helper molecules known as chaperones. These chaperones, or chaperonins, assist proteins in the complex folding process by preventing the aggregating of polypeptides, thus ensuring that proteins attain their functional three-dimensional conformation. Factors such as abnormal temperature or pH can hinder the proper folding of proteins, leading to a dysfunctional shape and a loss of protein function, a condition known as denaturation.