Final answer:
Switching from an MAOI to an SSRI typically involves a cross-taper method after a washout period to prevent serious interactions, as direct switch or additive combination can lead to severe reactions like serotonin syndrome.
Step-by-step explanation:
When changing from a Monoamine Oxidase Inhibitor (MAOI) to a Selective Serotonin Reuptake Inhibitor (SSRI), the recommended method is likely to involve a washing-out period where the MAOI is discontinued. This is to prevent serious interactions that can occur due to MAOIs' long-lasting effects on enzyme inhibition. Switching directly or using an additive combination can lead to severe adverse reactions such as serotonin syndrome. Therefore, the answer would be cross-taper, where the MAOI is gradually reduced while the SSRI is slowly introduced after an appropriate washout period to ensure MAOI levels have sufficiently decreased. This technique is preferred to reduce the risk of discontinuation symptoms from the MAOI and potential serotonin-related side effects from the SSRI.