Question

Nematode Model of Motor Neuron Disease

a. In which model is the study of Motor Neuron Disease conducted using nematodes?
b. What is the primary cause of Motor Neuron Disease in nematode models?
c. How do nematodes contribute to understanding Motor Neuron Disease?
d. Which receptor is targeted in nematode models for Motor Neuron Disease?

Answer 1

Motor Neuron Disease is studied using nematodes, specifically Caenorhabditis elegans, due to their value as a model system. The primary cause of MND in nematode models is gene mutation. Nematodes contribute to understanding MND by providing insights into cellular processes and interactions. The TAAR6 receptor/gene is targeted in nematode models for MND.

Step-by-step explanation:

Nematodes, specifically Caenorhabditis elegans (C. elegans), serve as a valuable model system for studying Motor Neuron Disease (MND). The primary cause of MND in nematode models is the mutation of certain genes that are homologous to those associated with MND in humans. By studying nematodes, scientists can gain insights into the mechanisms and processes involved in MND, including cellular interactions, cell fate determinations, and intracellular transport. In nematode models for MND, the TAAR6 receptor, specifically the TAAR6 gene, is targeted for investigation.